Endocrine Abstracts

Introduction: Exogenous Cushing’s syndrome is a challenging diagnosis in non-compliant patients or in cases with difficult anamnesis, while the access to self medication is relatively open.Aim: We present a young female case presenting with tertiary adrenal insufficiency.Case report: S.C., 40 years old has progressively weight gain of 30 kilos since the last year. The Body Mass Index is 40 kg/m2, with androgen redis...

Introduction: The heel Quantitative Ultrasound (QUS) evaluates the bone health, with good results if the clinical risk factors are also evaluated for each patient. Among these, the body mass index (BMI) may be protective or risk factor for a fragility fracture, depending on the values.Aim: We present a study in postmenpausal women evaluated by QUS and BMI.Patients & method: This is a study in 330 patients (women in menopause wh...

Introduction: Turner syndrome is a common cause of dwarfism and hypogonadism as is pituitary failure. However the association of the two is rarely thought and reported in the literature. We present two cases of women with hypogonadism diagnosed with Turner syndrome with various degrees of pituitary insuficiency.Case report: The first case presented at 16 years with secondary amenorrhea and showed slightly disharmonic dwarfism. A hypogonadotropic hypogona...

Disruption of the normal cell cycle is one of the most frequent alterations in tumour cells, contributing to uncontrolled cell proliferation during tumour development. The CDK inhibitor p27 plays a pivotal role in controlling cell proliferation during development and tumourigenesis, and has been implicated in tumorigenesis in rats. Previous studies have demonstrated changes in p27 protein expression, in human pituitary tumours,especially in corticotroph tumours, where p27 prot...

Leptin is a circulating hormone produced primarily by the adipose tissue, which controls food intake and energy homeostasis. Important peripheral actions of leptin involve inhibition of insulin biosynthesis and secretion in pancreatic ß-cells. In turn, insulin stimulates leptin secretion from adipose tissue, establishing a hormonal regulatory feedback loop: ‘adipo-insular axis’. The aim of our study was to determine the interrelations between leptin, insulin/ins...

Bone mass density and beta cross laps have been recognized as valid tests for the diagnostic and treatment control, as well as fracture prediction for osteoporotic patients. Statin treatment has been reported to be associated with a reduced risk fracture in these patients also. However, no studies, as of our knowledge, have tried to see if adding the lipid profile to the analysis of body mass density would improve the statistical power of prediction for any of the afore mentio...

Background: In patients with hyperparathyroidism, parathyroidectomy is the only curative therapy. Anesthetic management differs function of etiology (primary vs secondary or tertiary hyperparathyroidism) and surgical technique (minimally invasive or classic parathyroidectomy).Aim: To evaluate peri-operative management in parathyroidectomy for hyperparathyroidism of various etiologies, in a tertiary center.Patients and methods: Two ...

Introduction: Hyperthyroidism-associated myocardial infarction with normal epicardial coronary arteries on angiogram is seldom reported.Case report: A 61-year-old Caucasian man, resident in an iodine sufficient area, presented with chest pain in the emergency unit. ECG revealed inferolateral myocardial infarction with ST-segment elevation. Soon after admission, the patients developed collapse due to primary ventricular fibrillation, requiring defibrillat...

Background and Aim: Clinical and experimental studies demonstrated that total insulin-like growth factor 1 (IGF-1) levels are reduced in the patients with poorly controlled diabetes. The aim of the present study was to investigate the levels of IGF-1 in patients with acute metabolic acidosis.Materials and Methods: 17 patients with thype 1 diabetes and moderate or severe metabolic acidosis were recruited for this study. Serum levels of IGF-1 were determin...

Aim: To re-analyze the concept of echographic thyroid patterns (ETP) and clinical diagnostic in thyroidology, proposed 10 years ago.Material/method: i) Between 1996 and 2012, >25 000 thyroid ultrasound, linear probes, 7.5 MHz. ii) Description – eight ETP: pattern 0 – lack of thyroid, 1 – hypoechogenous pseudonodular; 2 – hypoecogen homogenous; 3 – micronodular hypoechogenous; 4 – macro (> 10 mm; ±micro) nodular;...